Official Symbol
S1PR4provided by HGNC
Official Full Name
sphingosine-1-phosphate receptor 4provided by HGNC
Primary source
HGNC:HGNC:3170
See related
Ensembl:ENSG00000125910 MIM:603751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDG6; LPC1; S1P4; SLP4
Summary
This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]
Orthologs
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Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (3178769..3180332)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3178767..3180330)

Chromosome 19 - NC_000019.10Genomic Neighboring Neighboring Neighboring Neighboring Neighboring Neighboring

Related articles in PubMed

  1. S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells. Dillmann C, et al. J Immunol, 2016 Feb 15. PMID 26783340
  2. A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor. Holdsworth G, et al. BMC Biochem, 2004 Aug 6. PMID 15298705, Free PMC Article
  3. Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. Candelore MR, et al. Biochem Biophys Res Commun, 2002 Sep 27. PMID 12270137
  4. Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. Idzko M, et al. FASEB J, 2002 Apr. PMID 11919175
  5. Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. Van Brocklyn JR, et al. Blood, 2000 Apr 15. PMID 10753843

See all (32) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Whats a GeneRIF?

  1. NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic biomarkers in patients with obstructive coronary artery: A weighted gene co-expression network analysis.

    Title: NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic biomarkers in patients with obstructive coronary artery: A weighted gene co-expression network analysis.

  2. T cell S1PR1 and S1PR4, and lymphatic endothelial cell (LEC) S1PR2, were required for migration across LECs and into lymphatic vessels and lymph nodes. S1PR1 and S1PR4 differentially regulated T cell motility and vascular cell adhesion molecule-1 (VCAM-1) binding. S1PR2 regulated LEC layer structure, permeability, and expression of the junction molecules VE-cadherin, occludin, and zonulin-1 through the ERK pathway.

    Title: CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration.

  3. High S1PR4 expression is associated with anti-neutrophil cytoplasmic antibody-associated vasculitis.

    Title: Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis.

  4. S1PR4 missense mutation is associated with variant blood cell traits.

    Title: Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits.

  5. Shear stress did not induce rapid dephosphorylation of beta-arrestin-1 or rapid internalization of S1P3, indicating no GPCR activation. These findings suggest that Galphaq/11 participates in the sensing/transducing of shear stress independently of GPCR activation in ECs.

    Title: Shear stress induces Gα<sub>q/11</sub> activation independently of G protein-coupled receptor activation in endothelial cells.

  6. Ig-like transcript 7 is rapidly internalized upon receptor-mediated endocytosis of TLR7/9 ligands to allow high IFN-alpha production. This is antagonized by S1PR4 signaling, thus decreasing TLR-induced IFN-alpha secretion.

    Title: S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells.

  7. S1P2 translocation to the nucleus is regulated by an autocrine loop involving S1P and S1P4. In contrast, the translocation of Y416 phosphorylated c-Src to the nucleus appears to be regulated by a mechanism that does not involve S1P3 or S1P4.

    Title: Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4.

  8. analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P-R) agonists

    Title: Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists.

  9. findings highlight an important role for S1P(4) and SK1 in ER(-) breast cancer progression.

    Title: Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer.

  10. Data show that S1P4 uses HER2 to regulate extracellular signal regulated kinase-1/2 MDA-MB-453 breast cancer cells.

    Title: Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells.

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Preferred Names
sphingosine 1-phosphate receptor 4
Names
S1P receptor 4
S1P receptor Edg-6
endothelial differentiation G-protein coupled receptor 6
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6
sphingosine 1-phosphate receptor Edg-6

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